Two of TV's hunks from Grey's Anatomy are set to join one heck of an all-star cast for Gary Marshall's new romantic comedy Valentine's Day. Patrick Dempsey and Eric Dane will be joining the film which is scheduled to arrive in theaters just before the real event on February 12, 2010.

According to Empire, the actors will be starring alongside an already great looking cast including Julia Roberts, Emma Roberts, Jessica Biel, Jessica Alba, Anne Hathaway, Jennifer Garner, Topher Grace, Bradley Cooper, Ashton Kutcher, and Shirley MacLaine. Dane will be playing a quarterback who’s not sure if he should retire, while Dempsey will play another an obstetrician who’s cheating on his wife with Jennifer Garner’s character, unbeknownst to her which is all taking overlapping with everyone elses stories centered in Los Angeles.

Is T.R. Knight looking to jump ship? Are ABC nixing same-sex storylines? Is Izzie romancing dead Denny just stupid? With debate swirling around Grey’s Anatomy at the moment, I wanted to take a lighter look at couplings that are on the horizon. Who’s the hottest of the potential love matches?

Personally speaking, I love Cristina (Sandra Oh can do no wrong) and her off-the-chart chemistry with McRambo AKA Owen (Kevin McKidd). Seriously, as Meredith might say, who didn’t see a touch of the old Grey’s magic in their steamy scene? I want vents like that at my work. More screengrabs and potential new pairings after the jump. READ MORE